U2AF1 mutation promotes tumorigenicity through facilitating autophagy flux mediated by FOXO3a activation in myelodysplastic syndromes

Mutations in the U2 small nuclear RNA auxiliary factor 1 (U2AF1) gene are the common feature of a major subset in myelodysplastic syndromes (MDS). However, the genetic landscape and molecular pathogenesis of oncogenic U2AF1(S34F) mutation in MDS are not totally understood. We performed comprehensive...

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Detalles Bibliográficos
Autores principales: Zhu, Yuqian, Song, Dandan, Guo, Juan, Jin, Jiacheng, Tao, Ying, Zhang, Zheng, Xu, Feng, He, Qi, Li, Xiao, Chang, Chunkang, Wu, Lingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238956/
https://www.ncbi.nlm.nih.gov/pubmed/34183647
http://dx.doi.org/10.1038/s41419-021-03573-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238956/
https://www.ncbi.nlm.nih.gov/pubmed/34183647
http://dx.doi.org/10.1038/s41419-021-03573-3

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