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A quantitative hematopoietic stem cell reconstitution protocol: Accounting for recipient variability, tissue distribution and cell half-lives

Hematopoietic stem and progenitor cell (HSPC) transplantation is the paradigm for stem cell therapies. The protocol described here enables quantitative assessment of the body-wide HSPC reconstitution of different mature hematopoietic cells in mice based on their presence in circulating blood. The me...

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Detalles Bibliográficos
Autores principales: Rajendiran, Smrithi, Boyer, Scott W., Forsberg, E. Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239062/
https://www.ncbi.nlm.nih.gov/pubmed/33486300
http://dx.doi.org/10.1016/j.scr.2020.102145