A Novel Orthotopic Implantation Technique for Osteosarcoma Produces Spontaneous Metastases and Illustrates Dose-Dependent Efficacy of B7-H3-CAR T Cells

The outcome for metastatic pediatric osteosarcoma (OS) remains poor. Thus, there is an urgent need to develop novel therapies, and immunotherapy with CAR T cells has the potential to meet this challenge. However, there is a lack of preclinical models that mimic salient features of human disease incl...

Descripción completa

Detalles Bibliográficos
Autores principales: Talbot, Lindsay Jones, Chabot, Ashley, Funk, Amy, Nguyen, Phuong, Wagner, Jessica, Ross, Aaron, Tillman, Heather, Davidoff, Andrew, Gottschalk, Stephen, DeRenzo, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239305/
https://www.ncbi.nlm.nih.gov/pubmed/34211478
http://dx.doi.org/10.3389/fimmu.2021.691741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239305/
https://www.ncbi.nlm.nih.gov/pubmed/34211478
http://dx.doi.org/10.3389/fimmu.2021.691741

Ejemplares similares