A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome–associated kinase Dyrk1A overexpression

The highly conserved dual-specificity tyrosine phosphorylation–regulated kinase 1A (Dyrk1A) plays crucial roles during central nervous system development and homeostasis. Furthermore, its hyperactivity is considered responsible for some neurological defects in individuals with Down syndrome. We set...

Descripción completa

Detalles Bibliográficos
Autores principales: Buchberger, Astrid, Schepergerdes, Lena, Flaßhoff, Maren, Kunick, Conrad, Köster, Reinhard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239740/
https://www.ncbi.nlm.nih.gov/pubmed/34090874
http://dx.doi.org/10.1016/j.jbc.2021.100853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239740/
https://www.ncbi.nlm.nih.gov/pubmed/34090874
http://dx.doi.org/10.1016/j.jbc.2021.100853

Ejemplares similares