In Vitro Analysis of N-Nitrosodimethylamine (NDMA) Formation From Ranitidine Under Simulated Gastrointestinal Conditions

IMPORTANCE: A publication reported that N-nitrosodimethylamine (NDMA), a probable human carcinogen, was formed when ranitidine and nitrite were added to simulated gastric fluid. However, the nitrite concentrations used were greater than the range detected in acidic gastric fluid in prior clinical st...

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Detalles Bibliográficos
Autores principales: Gao, Zongming, Karfunkle, Michael, Ye, Wei, Marzan, Tim Andres, Yang, Jingyue, Lex, Timothy, Sommers, Cynthia, Rodriguez, Jason D., Han, Xiaomei, Florian, Jeffry, Strauss, David G., Keire, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2021
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239951/
https://www.ncbi.nlm.nih.gov/pubmed/34181009
http://dx.doi.org/10.1001/jamanetworkopen.2021.18253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239951/
https://www.ncbi.nlm.nih.gov/pubmed/34181009
http://dx.doi.org/10.1001/jamanetworkopen.2021.18253

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