Cargando…

Tanshinone I exerts cardiovascular protective effects in vivo and in vitro through inhibiting necroptosis via Akt/Nrf2 signaling pathway

BACKGROUND: Tanshinone I (TI) is a primary component of Salvia miltiorrhiza Bunge (Danshen), which confers a favorable role in a variety of pharmacological activities including cardiovascular protection. However, the exact mechanism of the cardiovascular protection activity of TI remains to be illus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhuo, Youqiong, Yuan, Renyikun, Chen, Xinxin, He, Jia, Chen, Yangling, Zhang, Chenwei, Sun, Kaili, Yang, Shilin, Liu, Zhenjie, Gao, Hongwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240219/ https://www.ncbi.nlm.nih.gov/pubmed/34183021 http://dx.doi.org/10.1186/s13020-021-00458-7

Ejemplares similares

Sugarcane leaf polysaccharide exerts a therapeutic effect on cardiovascular diseases through necroptosis
por: Sun, Kaili, et al.
Publicado: (2023)

Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway
por: Wang, Qin-Qin, et al.
Publicado: (2021)

Discovery of New Heterocyclic/Benzofuran Hybrids as Potential Anti-Inflammatory Agents: Design, Synthesis, and Evaluation of the Inhibitory Activity of Their Related Inflammatory Factors Based on NF-κB and MAPK Signaling Pathways
por: Chen, Yangling, et al.
Publicado: (2023)

Hederasaponin C Alleviates Lipopolysaccharide-Induced Acute Lung Injury In Vivo and In Vitro Through the PIP2/NF-κB/NLRP3 Signaling Pathway
por: Han, Shan, et al.
Publicado: (2022)

Oleuropein Attenuates Lipopolysaccharide-Induced Acute Kidney Injury In Vitro and In Vivo by Regulating Toll-Like Receptor 4 Dimerization
por: Cui, Yushun, et al.
Publicado: (2021)

Simultaneous purification of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA from Salvia miltiorrhiza and their anti-inflammatory activities investigation
por: Gao, Hongwei, et al.
Publicado: (2018)

Sodium Tanshinone IIA Silate Exerts Microcirculation Protective Effects against Spinal Cord Injury In Vitro and In Vivo
por: Li, Xing, et al.
Publicado: (2020)

Anemoside B4 protects against Klebsiella pneumoniae- and influenza virus FM1-induced pneumonia via the TLR4/Myd88 signaling pathway in mice
por: He, Jia, et al.
Publicado: (2020)

Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells
por: Lin, C-Y, et al.
Publicado: (2016)

Fe-Curcumin Nanozyme-Mediated Reactive Oxygen Species Scavenging and Anti-Inflammation for Acute Lung Injury
por: Yuan, Renyikun, et al.
Publicado: (2021)

Cucurbitacin B inhibits TGF-β1-induced epithelial–mesenchymal transition (EMT) in NSCLC through regulating ROS and PI3K/Akt/mTOR pathways
por: Yuan, Renyikun, et al.
Publicado: (2022)

Tanshinone I Inhibits Oxidative Stress–Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling
por: Wu, Yu-Ting, et al.
Publicado: (2021)

Anti-Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis
por: Chen, Zhuo, et al.
Publicado: (2014)

Procyanidin A2, a polyphenolic compound, exerts anti-inflammatory and anti-oxidative activity in lipopolysaccharide-stimulated RAW264.7 cells
por: Wang, Qin-Qin, et al.
Publicado: (2020)

Tanshinones and diethyl blechnics with anti-inflammatory and anti-cancer activities from Salvia miltiorrhiza Bunge (Danshen)
por: Gao, Hongwei, et al.
Publicado: (2016)

Nrf2-dependent antioxidant response mediated the protective effect of tanshinone IIA on doxorubicin-induced cardiotoxicity
por: Guo, Zhaohui, et al.
Publicado: (2018)

The Role of Necroptosis in Cardiovascular Disease
por: Zhe-Wei, Shi, et al.
Publicado: (2018)

Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway
por: Gao, Hongwei, et al.
Publicado: (2017)

Tanshinone IIA protects mice against atherosclerotic injury by activating the TGF-β/PI3K/Akt/eNOS pathway
por: Wang, Junyan, et al.
Publicado: (2020)

Preparation, characterization, and in vivo evaluation of tanshinone IIA solid dispersions with silica nanoparticles
por: Jiang, Yan-rong, et al.
Publicado: (2013)

Tanshinone IIA inhibits angiogenesis in human endothelial progenitor cells in vitro and in vivo
por: Lee, Hsiang-Ping, et al.
Publicado: (2017)

Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway
por: Chen, Weiwei, et al.
Publicado: (2020)

Anemoside B4 Protects against Acute Lung Injury by Attenuating Inflammation through Blocking NLRP3 Inflammasome Activation and TLR4 Dimerization
por: Yuan, Renyikun, et al.
Publicado: (2020)

Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones
por: Zhai, Xifeng, et al.
Publicado: (2017)

Genome-wide characterisation and analysis of bHLH transcription factors related to tanshinone biosynthesis in Salvia miltiorrhiza
por: Zhang, Xin, et al.
Publicado: (2015)

Camptothecin Regulates Microglia Polarization and Exerts Neuroprotective Effects via Activating AKT/Nrf2/HO-1 and Inhibiting NF-κB Pathways In Vivo and In Vitro
por: He, Dewei, et al.
Publicado: (2021)

Pomiferin Exerts Antineuroinflammatory Effects through Activating Akt/Nrf2 Pathway and Inhibiting NF-κB Pathway
por: Zhao, Yan, et al.
Publicado: (2022)

Tanshinone I Mitigates Steroid-Induced Osteonecrosis of the Femoral Head and Activates the Nrf2 Signaling Pathway in Rats
por: Xu, Xilin, et al.
Publicado: (2021)

Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma
por: Liang, Xiaowei, et al.
Publicado: (2023)

Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway
por: Wang, Yanjun, et al.
Publicado: (2022)

Effect of Supplementation of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate on the Anticancer Effect of Epirubicin: An In Vitro Study
por: Chan, Szu-Erh, et al.
Publicado: (2011)

In Vivo Angiogenesis Screening and Mechanism of Action of Novel Tanshinone Derivatives Produced by One-Pot Combinatorial Modification of Natural Tanshinone Mixture from Salvia Miltiorrhiza
por: Zhang, Zhe-Rui, et al.
Publicado: (2014)

Non-coding RNAs in necroptosis, pyroptosis, and ferroptosis in cardiovascular diseases
por: Cai, Yuxi, et al.
Publicado: (2022)

Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling
por: Liu, Chang, et al.
Publicado: (2012)

Tanshinone IIA combined with cisplatin synergistically inhibits non‐small‐cell lung cancer in vitro and in vivo via down‐regulating the phosphatidylinositol 3‐kinase/Akt signalling pathway
por: Liao, Xiao‐Zhong, et al.
Publicado: (2019)

Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats via activating the Nrf2/ARE signalling pathway
por: Miao, Qing, et al.
Publicado: (2022)

Metabolism of Tanshinone IIA, Cryptotanshinone and Tanshinone I from Radix Salvia Miltiorrhiza in Zebrafish
por: Wei, Yingjie, et al.
Publicado: (2012)

Salvia columbariae contains tanshinones
por: Adams, James D., et al.
Publicado: (2005)

The mechanisms of tanshinone in the treatment of tumors
por: Zhang, Pengyu, et al.
Publicado: (2023)

Necroptosis: A Novel Pathway in Neuroinflammation
por: Yu, Ziyu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_65fdn0onb4s29aer5947aic0v8