Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts

Resistance to CD19-directed immunotherapies in lymphoblastic leukemia has been attributed, among other factors, to several aberrant CD19 pre-mRNA splicing events, including recently reported excision of a cryptic intron embedded within CD19 exon 2. While “exitrons” are known to exist in hundreds of...

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Detalles Bibliográficos
Autores principales: Schulz, Laura, Torres-Diz, Manuel, Cortés-López, Mariela, Hayer, Katharina E., Asnani, Mukta, Tasian, Sarah K., Barash, Yoseph, Sotillo, Elena, Zarnack, Kathi, König, Julian, Thomas-Tikhonenko, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240250/
https://www.ncbi.nlm.nih.gov/pubmed/34183059
http://dx.doi.org/10.1186/s13059-021-02411-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240250/
https://www.ncbi.nlm.nih.gov/pubmed/34183059
http://dx.doi.org/10.1186/s13059-021-02411-1

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