Dual targeting of l-carnitine-conjugated nanoparticles to OCTN2 and ATB(0,+) to deliver chemotherapeutic agents for colon cancer therapy

l-Carnitine, obligatory for oxidation of fatty acids, is transported into cells by the Na(+)-coupled transporter OCTN2 and the Na(+)/Cl(–)-coupled transporter ATB(0,+). Here we investigated the potential of L-carnitine-conjugated poly(lactic-co-glycolic acid) (PLGA) nanoparticles (LC-PLGA NPs) to de...

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Detalles Bibliográficos
Autores principales: Kou, Longfa, Yao, Qing, Sivaprakasam, Sathish, Luo, Qiuhua, Sun, Yinghua, Fu, Qiang, He, Zhonggui, Sun, Jin, Ganapathy, Vadivel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241000/
https://www.ncbi.nlm.nih.gov/pubmed/28911246
http://dx.doi.org/10.1080/10717544.2017.1377316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241000/
https://www.ncbi.nlm.nih.gov/pubmed/28911246
http://dx.doi.org/10.1080/10717544.2017.1377316

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