In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration

Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal delivery of DTZ. Niosomes protect hydrophilic drugs inside their core while nasal route offers both...

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Detalles Bibliográficos
Autores principales: Ammar, H. O., Haider, M., Ibrahim, M., El Hoffy, N. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241015/
https://www.ncbi.nlm.nih.gov/pubmed/28165822
http://dx.doi.org/10.1080/10717544.2016.1259371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241015/
https://www.ncbi.nlm.nih.gov/pubmed/28165822
http://dx.doi.org/10.1080/10717544.2016.1259371

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