Transdermal agomelatine microemulsion gel: pyramidal screening, statistical optimization and in vivo bioavailability

Agomelatine is a new antidepressant having very low oral drug bioavailability less than 5% due to being liable to extensive hepatic 1st pass effect. This study aimed to deliver agomelatine by transdermal route through formulation and optimization of microemulsion gel. Pyramidal screening was perform...

Descripción completa

Detalles Bibliográficos
Autores principales: Said, Mayada, Elsayed, Ibrahim, Aboelwafa, Ahmed A., Elshafeey, Ahmed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241019/
https://www.ncbi.nlm.nih.gov/pubmed/28831842
http://dx.doi.org/10.1080/10717544.2017.1365392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241019/
https://www.ncbi.nlm.nih.gov/pubmed/28831842
http://dx.doi.org/10.1080/10717544.2017.1365392

Ejemplares similares