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Transdermal agomelatine microemulsion gel: pyramidal screening, statistical optimization and in vivo bioavailability

Agomelatine is a new antidepressant having very low oral drug bioavailability less than 5% due to being liable to extensive hepatic 1st pass effect. This study aimed to deliver agomelatine by transdermal route through formulation and optimization of microemulsion gel. Pyramidal screening was perform...

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Detalles Bibliográficos
Autores principales:	Said, Mayada, Elsayed, Ibrahim, Aboelwafa, Ahmed A., Elshafeey, Ahmed H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241019/ https://www.ncbi.nlm.nih.gov/pubmed/28831842 http://dx.doi.org/10.1080/10717544.2017.1365392

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