Nanotransfersomes-loaded thermosensitive in situ gel as a rectal delivery system of tizanidine HCl: preparation, in vitro and in vivo performance

The purpose of the current study was to develop tizanidine HCl (TIZ; a myotonolytic agent used for treatment of spasticity) loaded nanotransfersomes intended for rectal administration, aiming to bypass the hepatic first-pass metabolism. TIZ-loaded nanotransfersomes were prepared by thin-film hydrati...

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Detalles Bibliográficos
Autores principales: Moawad, Fatma A., Ali, Adel A., Salem, Heba F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241079/
https://www.ncbi.nlm.nih.gov/pubmed/28156169
http://dx.doi.org/10.1080/10717544.2016.1245369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241079/
https://www.ncbi.nlm.nih.gov/pubmed/28156169
http://dx.doi.org/10.1080/10717544.2016.1245369

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