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Assessment of solid microneedle rollers to enhance transmembrane delivery of doxycycline and inhibition of MMP activity
Many chronic wounds exhibit high matrix metalloproteinase (MMP) activity that impedes the normal wound healing process. Intradermal delivery (IDD) of sub-antimicrobial concentrations of doxycycline, as an MMP inhibitor, could target early stages of chronic wound development and inhibit further wound...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241162/ https://www.ncbi.nlm.nih.gov/pubmed/28618841 http://dx.doi.org/10.1080/10717544.2017.1337826 |