A novel core-shell lipid nanoparticle for improving oral administration of water soluble chemotherapeutic agents: inhibited intestinal hydrolysis and enhanced lymphatic absorption

The oral administration of water-soluble chemotherapeutical agents is limited by their serious gastrointestinal side effects, instability at intestinal pH, and poor absorption. Aiming to solve these problems, we chose topotecan (TPT) as a model drug and developed a novel lipid formulation containing...

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Detalles Bibliográficos
Autores principales: Wang, Tao, Shen, Liao, Zhang, Zhen, Li, Haiyan, Huang, Ri, Zhang, Yadan, Quan, Dongqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241165/
https://www.ncbi.nlm.nih.gov/pubmed/29029577
http://dx.doi.org/10.1080/10717544.2017.1386730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241165/
https://www.ncbi.nlm.nih.gov/pubmed/29029577
http://dx.doi.org/10.1080/10717544.2017.1386730

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