Loratadine bioavailability via buccal transferosomal gel: formulation, statistical optimization, in vitro/in vivo characterization, and pharmacokinetics in human volunteers

Loratadine (LTD) is an antihistaminic drug that suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly variable oral absorption. This study was undertaken to develop and statistically optimize transfersomal gel for transbuccal delivery of LTD. Tr...

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Detalles Bibliográficos
Autores principales: Elkomy, Mohammed H., El Menshawe, Shahira F., Abou-Taleb, Heba A., Elkarmalawy, Marwa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241167/
https://www.ncbi.nlm.nih.gov/pubmed/28480758
http://dx.doi.org/10.1080/10717544.2017.1321061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241167/
https://www.ncbi.nlm.nih.gov/pubmed/28480758
http://dx.doi.org/10.1080/10717544.2017.1321061

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