Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation

The majority of drug candidates fails the approval phase due to unwanted toxicities and side effects. Establishment of an effective toxicity prediction platform is of utmost importance, to increase the efficiency of the drug discovery process. For this purpose, we developed a toxicity prediction pla...

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Detalles Bibliográficos
Autores principales: Kadioglu, Onat, Klauck, Sabine M., Fleischer, Edmond, Shan, Letian, Efferth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241674/
https://www.ncbi.nlm.nih.gov/pubmed/34021777
http://dx.doi.org/10.1007/s00204-021-03058-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241674/
https://www.ncbi.nlm.nih.gov/pubmed/34021777
http://dx.doi.org/10.1007/s00204-021-03058-4

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