Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification

Hepatic organoids are a recent innovation in in vitro modeling. Initial studies suggest that organoids better recapitulate the liver phenotype in vitro compared to pre-existing proliferative cell models. However, their potential for drug metabolism and detoxification remains poorly characterized, an...

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Detalles Bibliográficos
Autores principales: Howell, Lawrence, Jenkins, Rosalind E., Lynch, Stephen, Duckworth, Carrie, Kevin Park, B., Goldring, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Toxicogenomics and Omics Technologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241807/
https://www.ncbi.nlm.nih.gov/pubmed/34050779
http://dx.doi.org/10.1007/s00204-021-03075-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241807/
https://www.ncbi.nlm.nih.gov/pubmed/34050779
http://dx.doi.org/10.1007/s00204-021-03075-3

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