Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase

PrimPol is a human DNA polymerase-primase that localizes to mitochondria and nucleus and bypasses the major oxidative lesion 7,8-dihydro-8-oxoguanine (oxoG) via translesion synthesis, in mostly error-free manner. We present structures of PrimPol insertion complexes with a DNA template-primer and cor...

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Detalles Bibliográficos
Autores principales: Rechkoblit, Olga, Johnson, Robert E., Gupta, Yogesh K., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241999/
https://www.ncbi.nlm.nih.gov/pubmed/34188055
http://dx.doi.org/10.1038/s41467-021-24317-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241999/
https://www.ncbi.nlm.nih.gov/pubmed/34188055
http://dx.doi.org/10.1038/s41467-021-24317-z

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