Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia

CD33/Sialic acid-binding Ig-like lectin 3 (SIGLEC3) is an innate immune receptor expressed on myeloid cells and mediates inhibitory signaling via tyrosine phosphatases. Variants of CD33 are associated with Alzheimer’s disease (AD) suggesting that modulation of CD33 signaling might be beneficial in A...

Descripción completa

Detalles Bibliográficos
Autores principales: Wißfeld, Jannis, Mathews, Mona, Mossad, Omar, Picardi, Paola, Cinti, Alessandro, Redaelli, Loredana, Pradier, Laurent, Brüstle, Oliver, Neumann, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242067/
https://www.ncbi.nlm.nih.gov/pubmed/34188106
http://dx.doi.org/10.1038/s41598-021-92434-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242067/
https://www.ncbi.nlm.nih.gov/pubmed/34188106
http://dx.doi.org/10.1038/s41598-021-92434-2

Ejemplares similares