Allosteric drug transport mechanism of multidrug transporter AcrB

Gram-negative bacteria maintain an intrinsic resistance mechanism against entry of noxious compounds by utilizing highly efficient efflux pumps. The E. coli AcrAB-TolC drug efflux pump contains the inner membrane H(+)/drug antiporter AcrB comprising three functionally interdependent protomers, cycli...

Descripción completa

Detalles Bibliográficos
Autores principales: Tam, Heng-Keat, Foong, Wuen Ee, Oswald, Christine, Herrmann, Andrea, Zeng, Hui, Pos, Klaas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242077/
https://www.ncbi.nlm.nih.gov/pubmed/34188038
http://dx.doi.org/10.1038/s41467-021-24151-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242077/
https://www.ncbi.nlm.nih.gov/pubmed/34188038
http://dx.doi.org/10.1038/s41467-021-24151-3

Ejemplares similares