Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity

The vast majority of human tumors with p53 mutations undergo loss of the remaining wildtype p53 allele (loss-of-heterozygosity, p53LOH). p53LOH has watershed significance in promoting tumor progression. However, driving forces for p53LOH are poorly understood. Here we identify the repressive WTp53–H...

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Detalles Bibliográficos
Autores principales: Isermann, Tamara, Şener, Özge Çiçek, Stender, Adrian, Klemke, Luisa, Winkler, Nadine, Neesse, Albrecht, Li, Jinyu, Wegwitz, Florian, Moll, Ute M., Schulz-Heddergott, Ramona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242083/
https://www.ncbi.nlm.nih.gov/pubmed/34188043
http://dx.doi.org/10.1038/s41467-021-24064-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242083/
https://www.ncbi.nlm.nih.gov/pubmed/34188043
http://dx.doi.org/10.1038/s41467-021-24064-1

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