ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure

The widely expressed and poly-specific ABC transporters breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1) are co-localized at the blood-brain barrier (BBB) and have shown to limit the brain distribution of several clinically used ABCB1/ABCG2 substrate drugs. It is currently not kno...

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Detalles Bibliográficos
Autores principales: El Biali, Myriam, Karch, Rudolf, Philippe, Cécile, Haslacher, Helmuth, Tournier, Nicolas, Hacker, Marcus, Zeitlinger, Markus, Schmidl, Doreen, Langer, Oliver, Bauer, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242189/
https://www.ncbi.nlm.nih.gov/pubmed/34220523
http://dx.doi.org/10.3389/fphar.2021.698966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242189/
https://www.ncbi.nlm.nih.gov/pubmed/34220523
http://dx.doi.org/10.3389/fphar.2021.698966

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