Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter

The mitochondrial calcium uniporter (MCU), the highly selective channel responsible for mitochondrial Ca(2+) entry, plays important roles in physiology and pathology. However, only few pharmacological compounds directly and selectively modulate its activity. Here, we perform high-throughput screenin...

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Detalles Bibliográficos
Autores principales: De Mario, Agnese, Tosatto, Anna, Hill, Julia Marie, Kriston-Vizi, Janos, Ketteler, Robin, Vecellio Reane, Denis, Cortopassi, Gino, Szabadkai, Gyorgy, Rizzuto, Rosario, Mammucari, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242467/
https://www.ncbi.nlm.nih.gov/pubmed/34161774
http://dx.doi.org/10.1016/j.celrep.2021.109275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242467/
https://www.ncbi.nlm.nih.gov/pubmed/34161774
http://dx.doi.org/10.1016/j.celrep.2021.109275

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