Depletion of Kruppel-like factor 15 sensitized gliomas to temozolomide cytotoxicity through O(6)-methylguanine-DNA methyl-transferase

Temozolomide (TMZ)-based chemotherapy is a standard strategy for gliomas, although chemoresistance remains a major therapeutic challenge. The chemical mechanism by which TMZ induces cell death is DNA methylation, leading to double-stranded breaks (DSBs) and thus to apoptosis. However, TMZ-induced N6...

Descripción completa

Detalles Bibliográficos
Autores principales: Qu, Xinjuan, Liu, Xuelai, Zhang, Yumei, Shi, Zhan, Wang, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242961/
https://www.ncbi.nlm.nih.gov/pubmed/34222684
http://dx.doi.org/10.1016/j.bbrep.2021.101058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242961/
https://www.ncbi.nlm.nih.gov/pubmed/34222684
http://dx.doi.org/10.1016/j.bbrep.2021.101058

Ejemplares similares