p53 mitigates the effects of oncogenic HRAS in urothelial cells via the repression of MCOLN1

Inhibition of TRPML1, which is encoded by MCOLN1, is known to deter cell proliferation in various malignancies. Here, we report that the tumor suppressor, p53, represses MCOLN1 in the urothelium such that either the constitutive loss or ectopic knockdown of TP53—in both healthy and bladder cancer ce...

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Detalles Bibliográficos
Autores principales: Jung, Jewon, Liao, Han, Coker, Shannon A., Liang, Hong, Hancock, John F., Denicourt, Catherine, Venkatachalam, Kartik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243020/
https://www.ncbi.nlm.nih.gov/pubmed/34222845
http://dx.doi.org/10.1016/j.isci.2021.102701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243020/
https://www.ncbi.nlm.nih.gov/pubmed/34222845
http://dx.doi.org/10.1016/j.isci.2021.102701

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