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Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis
Phospholipidosis, the excessive accumulation of phospholipids within lysosomes, is a pathological response observed following exposure to many drugs across multiple therapeutic groups. A clear mechanistic understanding of the causes and implications of this form of drug toxicity has remained elusive...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243516/ https://www.ncbi.nlm.nih.gov/pubmed/34087196 http://dx.doi.org/10.1016/j.jlr.2021.100089 |