Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis

Phospholipidosis, the excessive accumulation of phospholipids within lysosomes, is a pathological response observed following exposure to many drugs across multiple therapeutic groups. A clear mechanistic understanding of the causes and implications of this form of drug toxicity has remained elusive...

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Detalles Bibliográficos
Autores principales: Hinkovska-Galcheva, Vania, Treadwell, Taylour, Shillingford, Jonathan M., Lee, Angela, Abe, Akira, Tesmer, John J.G., Shayman, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243516/
https://www.ncbi.nlm.nih.gov/pubmed/34087196
http://dx.doi.org/10.1016/j.jlr.2021.100089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243516/
https://www.ncbi.nlm.nih.gov/pubmed/34087196
http://dx.doi.org/10.1016/j.jlr.2021.100089

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