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Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds
Since the advances in protein engineering and manufacture, over the last 30 years, antibody-based immunotherapeutic has become a powerful strategy to treat diseases. The T-cell engaging bispecific antibody (BsAb) by combining the Fab binding domain of tumor antigens and Fab or single-chain variable...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243740/ https://www.ncbi.nlm.nih.gov/pubmed/34187511 http://dx.doi.org/10.1186/s13036-021-00272-7 |