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Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds

Since the advances in protein engineering and manufacture, over the last 30 years, antibody-based immunotherapeutic has become a powerful strategy to treat diseases. The T-cell engaging bispecific antibody (BsAb) by combining the Fab binding domain of tumor antigens and Fab or single-chain variable...

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Detalles Bibliográficos
Autores principales:	Yu, Lin, Huang, Nan, Ge, Liangpeng, Sun, Heng, Fu, Yuna, Liu, Chundong, Wang, Jianhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243740/ https://www.ncbi.nlm.nih.gov/pubmed/34187511 http://dx.doi.org/10.1186/s13036-021-00272-7

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