Sequence sensitivity and pH dependence of maleimide conjugated N‐terminal cysteine peptides to thiazine rearrangement

Thiazine formation during the conjugation of N‐terminal cysteine peptides to maleimides is an underreported side reaction in the peptide literature. When the conjugation was performed at neutral and basic pH, we observed the thiazine isomer as a significant by‐product. Nuclear magnetic resonance (NM...

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Detalles Bibliográficos
Autores principales: Gober, Isaiah N., Riemen, Alexander J., Villain, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243948/
https://www.ncbi.nlm.nih.gov/pubmed/33786923
http://dx.doi.org/10.1002/psc.3323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243948/
https://www.ncbi.nlm.nih.gov/pubmed/33786923
http://dx.doi.org/10.1002/psc.3323

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