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Elevated activity levels of activating autoantibodies to the GnRH receptor in patients with polycystic ovary syndrome

OBJECTIVES: 1) To confirm the correlation of GnRH receptor (GnRHR) activating autoantibody (AAb) activity with polycystic ovary syndrome (PCOS) diagnosis in large well defined cohorts; and 2) to evaluate suppression of AAb activity with GnRH antagonist medication in transfected GnRHR cells exposed t...

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Detalles Bibliográficos
Autores principales: Weedin, Elizabeth A., Burks, Heather R., Yu, Xichun, Li, Hong Liang, Aston, Christopher E., Kem, David C., Craig, LaTasha B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244267/
https://www.ncbi.nlm.nih.gov/pubmed/34223260
http://dx.doi.org/10.1016/j.xfre.2020.09.015