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A two-stage computational approach to predict novel ligands for a chemosensory receptor

Olfactory receptor (OR) 1A2 is the member of largest superfamily of G protein-coupled receptors (GPCRs). OR1A2 is an ectopically expressed receptor with only 13 known ligands, implicated in reducing hepatocellular carcinoma progression, with enormous therapeutic potential. We have developed a two-st...

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Detalles Bibliográficos
Autores principales: Jabeen, Amara, Vijayram, Ramya, Ranganathan, Shoba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244491/
https://www.ncbi.nlm.nih.gov/pubmed/34235481
http://dx.doi.org/10.1016/j.crstbi.2020.10.001