Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia

Impaired liver function may lead to hyperammonemia and risk for hepatic encephalopathy. In brain, detoxification of ammonia is mediated mainly by glutamine synthetase (GS) in astrocytes. This requires a continuous de novo synthesis of glutamate, likely involving the action of both pyruvate carboxyla...

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Detalles Bibliográficos
Autores principales: Voss, Caroline M., Arildsen, Lene, Nissen, Jakob D., Waagepetersen, Helle S., Schousboe, Arne, Maechler, Pierre, Ott, Peter, Vilstrup, Hendrik, Walls, Anne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244593/
https://www.ncbi.nlm.nih.gov/pubmed/34220417
http://dx.doi.org/10.3389/fnins.2021.646291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244593/
https://www.ncbi.nlm.nih.gov/pubmed/34220417
http://dx.doi.org/10.3389/fnins.2021.646291

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