Oral (−)-Epicatechin Inhibits Progressive Tau Pathology in rTg4510 Mice Independent of Direct Actions at GSK3β

Aggregation of the microtubule-associated protein tau into paired helical filaments (PHFs) and neurofibrillary tangles is a defining characteristic of Alzheimer’s Disease. Various plant polyphenols disrupt tau aggregation in vitro but display poor bioavailability and low potency, challenging their t...

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Detalles Bibliográficos
Autores principales: Hole, Katriona L., Staniaszek, Lydia E., Menon Balan, Gayathri, Mason, Jody M., Brown, Jon T., Williams, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244787/
https://www.ncbi.nlm.nih.gov/pubmed/34220446
http://dx.doi.org/10.3389/fnins.2021.697319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244787/
https://www.ncbi.nlm.nih.gov/pubmed/34220446
http://dx.doi.org/10.3389/fnins.2021.697319

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