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In vitro engineering of a bone metastases model allows for study of the effects of antiandrogen therapies in advanced prostate cancer

While androgen-targeted therapies are routinely used in advanced prostate cancer (PCa), their effect is poorly understood in treating bone metastatic lesions and ultimately results in the development of metastatic castrate resistant prostate cancer (mCRPC). Here, we used an all-human microtissue-eng...

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Detalles Bibliográficos
Autores principales: Bock, Nathalie, Kryza, Thomas, Shokoohmand, Ali, Röhl, Joan, Ravichandran, Akhilandeshwari, Wille, Marie-Luise, Nelson, Colleen C., Hutmacher, Dietmar W., Clements, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245033/
https://www.ncbi.nlm.nih.gov/pubmed/34193425
http://dx.doi.org/10.1126/sciadv.abg2564