Microfluidic ion stripper for removal of trifluoroacetic acid from mobile phases used in HILIC-MS of intact proteins

Trifluoroacetic acid (TFA) is commonly used as mobile phase additive to improve retention and peak shape characteristics in hydrophilic interaction liquid chromatography (HILIC) of intact proteins. However, when using electrospray ionization-mass spectrometry (ESI-MS) detection, TFA may cause ioniza...

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Detalles Bibliográficos
Autores principales: Wouters, Sam, Eeltink, Sebastiaan, Haselberg, Rob, Somsen, Govert W., Gargano, Andrea F. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245364/
https://www.ncbi.nlm.nih.gov/pubmed/34050389
http://dx.doi.org/10.1007/s00216-021-03414-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245364/
https://www.ncbi.nlm.nih.gov/pubmed/34050389
http://dx.doi.org/10.1007/s00216-021-03414-4

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