Cargando…
Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
Demand for a cure of liver fibrosis is rising with its increasing morbidity and mortality. Therefore, it is an urgent issue to investigate its therapeutic candidates. Liver fibrosis progresses following ‘multi-hit’ processes involving hepatic stellate cells, macrophages, and hepatocytes. The NOD-lik...
Autores principales: | Kim, Hyun Young, Choi, Young Jae, Kim, Sang Kyum, Kim, Hyunsung, Jun, Dae Won, Yoon, Kyungrok, Kim, Nayoun, Hwang, Jungwook, Kim, Young-Mi, Lim, Sung Chul, Kang, Keon Wook |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245406/ https://www.ncbi.nlm.nih.gov/pubmed/34193972 http://dx.doi.org/10.1038/s42003-021-02345-1 |
Ejemplares similares
-
Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin
por: Kim, Hyun Young, et al.
Publicado: (2023) -
Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of κB Kinase and Inflammasome-Mediated Interleukin-1β Secretion
por: Kim, Hyun Young, et al.
Publicado: (2019) -
Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro
por: Hwangbo, Hyun, et al.
Publicado: (2020) -
SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome Activation
por: Kim, Na-Eun, et al.
Publicado: (2021) -
The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney
por: Kim, Yang Gyun, et al.
Publicado: (2019)