Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations

Aberrantly expressed fused in sarcoma (FUS) is a hallmark of FUS-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Wildtype FUS localises to synapses and interacts with mitochondrial proteins while mutations have been shown to cause to pathological changes affecting mito...

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Detalles Bibliográficos
Autores principales: Salam, Shaakir, Tacconelli, Sara, Smith, Bradley N., Mitchell, Jacqueline C., Glennon, Elizabeth, Nikolaou, Nikolas, Houart, Corinne, Vance, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245466/
https://www.ncbi.nlm.nih.gov/pubmed/34193962
http://dx.doi.org/10.1038/s41598-021-93189-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245466/
https://www.ncbi.nlm.nih.gov/pubmed/34193962
http://dx.doi.org/10.1038/s41598-021-93189-6

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