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Biophysical properties of a tau seed

Pathogenesis of tauopathies involves conversion of tau monomer into pathological tau conformers that serve as templates to recruit native tau into growing assemblies. Small soluble tau seeds have been proposed to drive pathological tau assembly in vitro, in cells and in vivo. We have previously desc...

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Detalles Bibliográficos
Autores principales: Hou, Zhiqiang, Chen, Dailu, Ryder, Bryan D., Joachimiak, Lukasz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245522/
https://www.ncbi.nlm.nih.gov/pubmed/34193922
http://dx.doi.org/10.1038/s41598-021-93093-z