RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains

RAS proteins are lipid-anchored small GTPases that switch between the GTP-bound active and GDP-bound inactive states. RAS isoforms, including HRAS, NRAS and splice variants KRAS4A and KRAS4B, are some of the most frequently mutated proteins in cancer. In particular, constitutively active mutants of...

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Detalles Bibliográficos
Autores principales: Zhou, Yong, Gorfe, Alemayehu A., Hancock, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245699/
https://www.ncbi.nlm.nih.gov/pubmed/34222339
http://dx.doi.org/10.3389/fmolb.2021.686338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245699/
https://www.ncbi.nlm.nih.gov/pubmed/34222339
http://dx.doi.org/10.3389/fmolb.2021.686338

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