Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment

Remdesivir (RDV) is the only US Food and Drug Administration (FDA)-approved drug for treating COVID-19. However, RDV can only be given by intravenous route, and there is a pressing medical need for oral antivirals. Significant evidence suggests that the role of the parent nucleoside GS-441524 in the...

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Detalles Bibliográficos
Autores principales: Xie, Jiashu, Wang, Zhengqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245906/
https://www.ncbi.nlm.nih.gov/pubmed/34221871
http://dx.doi.org/10.1016/j.apsb.2021.03.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245906/
https://www.ncbi.nlm.nih.gov/pubmed/34221871
http://dx.doi.org/10.1016/j.apsb.2021.03.028

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