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An engineered biosynthetic–synthetic platform for production of halogenated indolmycin antibiotics

Indolmycin is an antibiotic from Streptomyces griseus ATCC 12648 with activity against Helicobacter pylori, Plasmodium falciparum, and methicillin-resistant Staphylococcus aureus. Here we describe the use of the indolmycin biosynthetic genes in E. coli to make indolmycenic acid, a chiral intermediat...

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Detalles Bibliográficos
Autores principales:	Hoffarth, Elesha R., Kong, Sunnie, He, Hai-Yan, Ryan, Katherine S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246080/ https://www.ncbi.nlm.nih.gov/pubmed/34257882 http://dx.doi.org/10.1039/d0sc05843b

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