Carbene-catalyzed enantioselective annulation of dinucleophilic hydrazones and bromoenals for access to aryl-dihydropyridazinones and related drugs

4,5-Dihydropyridazinones bearing an aryl substituent at the C6-position are important motifs in drug molecules. Herein, we developed an efficient protocol to access aryl-dihydropyridazinone molecules via carbene-catalyzed asymmetric annulation between dinucleophilic arylidene hydrazones and bromoena...

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Detalles Bibliográficos
Autores principales: Mondal, Bivas, Maiti, Rakesh, Yang, Xing, Xu, Jun, Tian, Weiyi, Yan, Jia-Lei, Li, Xiangyang, Chi, Yonggui Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246082/
https://www.ncbi.nlm.nih.gov/pubmed/34257877
http://dx.doi.org/10.1039/d1sc01891d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246082/
https://www.ncbi.nlm.nih.gov/pubmed/34257877
http://dx.doi.org/10.1039/d1sc01891d

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