Mapping the binding site topology of amyloid protein aggregates using multivalent ligands

A key process in the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is the aggregation of proteins to produce fibrillary aggregates with a cross β-sheet structure, amyloid. The development of reagents that can bind these aggregates with high affinity...

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Detalles Bibliográficos
Autores principales: Sanna, Elena, Rodrigues, Margarida, Fagan, Steven G., Chisholm, Timothy S., Kulenkampff, Klara, Klenerman, David, Spillantini, Maria Grazia, Aigbirhio, Franklin I., Hunter, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246084/
https://www.ncbi.nlm.nih.gov/pubmed/34257890
http://dx.doi.org/10.1039/d1sc01263k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246084/
https://www.ncbi.nlm.nih.gov/pubmed/34257890
http://dx.doi.org/10.1039/d1sc01263k

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