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Bayesian optimization with evolutionary and structure-based regularization for directed protein evolution
BACKGROUND: Directed evolution (DE) is a technique for protein engineering that involves iterative rounds of mutagenesis and screening to search for sequences that optimize a given property, such as binding affinity to a specified target. Unfortunately, the underlying optimization problem is under-d...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246133/ https://www.ncbi.nlm.nih.gov/pubmed/34210336 http://dx.doi.org/10.1186/s13015-021-00195-4 |