Skeletal muscle proteomes reveal downregulation of mitochondrial proteins in transition from prediabetes into type 2 diabetes

Skeletal muscle insulin resistance is a central defect in the pathogenesis of type 2 diabetes (T2D). Here, we analyzed skeletal muscle proteome in 148 vastus lateralis muscle biopsies obtained from men covering all glucose tolerance phenotypes: normal, impaired fasting glucose (IFG), impaired glucos...

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Detalles Bibliográficos
Autores principales: Öhman, Tiina, Teppo, Jaakko, Datta, Neeta, Mäkinen, Selina, Varjosalo, Markku, Koistinen, Heikki A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246593/
https://www.ncbi.nlm.nih.gov/pubmed/34235411
http://dx.doi.org/10.1016/j.isci.2021.102712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246593/
https://www.ncbi.nlm.nih.gov/pubmed/34235411
http://dx.doi.org/10.1016/j.isci.2021.102712

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