Alzheimer’s protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity

Several mutations conferring protection against Alzheimer's disease (AD) have been described, none as profound as the A673T mutation, where carriers are four times less likely to get AD compared to noncarriers. This mutation results in reduced amyloid beta (Aβ) protein production in vitro and l...

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Detalles Bibliográficos
Autores principales: Limegrover, Colleen S., LeVine, Harry, Izzo, Nicholas J., Yurko, Raymond, Mozzoni, Kelsie, Rehak, Courtney, Sadlek, Kelsey, Safferstein, Hank, Catalano, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246829/
https://www.ncbi.nlm.nih.gov/pubmed/33025581
http://dx.doi.org/10.1111/jnc.15212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246829/
https://www.ncbi.nlm.nih.gov/pubmed/33025581
http://dx.doi.org/10.1111/jnc.15212

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