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Alzheimer’s protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity
Several mutations conferring protection against Alzheimer's disease (AD) have been described, none as profound as the A673T mutation, where carriers are four times less likely to get AD compared to noncarriers. This mutation results in reduced amyloid beta (Aβ) protein production in vitro and l...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246829/ https://www.ncbi.nlm.nih.gov/pubmed/33025581 http://dx.doi.org/10.1111/jnc.15212 |