Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum

BACKGROUND: Anti-malarial drug resistance may be limited by decreased fitness in resistant parasites. Important contributors to resistance are mutations in the Plasmodium falciparum putative drug transporter PfMDR1. METHODS: Impacts on in vitro fitness of two common PfMDR1 polymorphisms, N86Y, which...

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Detalles Bibliográficos
Autores principales: Duvalsaint, Marvin, Conrad, Melissa D., Tukwasibwe, Stephen, Tumwebaze, Patrick K., Legac, Jennifer, Cooper, Roland A., Rosenthal, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247092/
https://www.ncbi.nlm.nih.gov/pubmed/34193148
http://dx.doi.org/10.1186/s12936-021-03823-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247092/
https://www.ncbi.nlm.nih.gov/pubmed/34193148
http://dx.doi.org/10.1186/s12936-021-03823-x

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