Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage

BACKGROUND: Irinotecan (CPT-11) is clinically known to cause severe diarrhea and gastrointestinal damage. Recently, we have reported that CPT-11-induced gastrointestinal damage is associated with the upregulation of intestinal P-glycoprotein (P-gp) expression and decreased absorption of its substrat...

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Detalles Bibliográficos
Autores principales: Tsuchitani, Toshiaki, Akiyoshi, Takeshi, Imaoka, Ayuko, Ohtani, Hisakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247139/
https://www.ncbi.nlm.nih.gov/pubmed/34193275
http://dx.doi.org/10.1186/s40780-021-00207-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247139/
https://www.ncbi.nlm.nih.gov/pubmed/34193275
http://dx.doi.org/10.1186/s40780-021-00207-w

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